Insulin Resistance and Inositol

You might have heard the PCOS buzzword, “Inositol,” in your recent research regarding PCOS. What is it? What does it do? Could it actually help you? The answer is – it might!

When I was looking into natural alternatives for Metformin, I came across this research study on the effect of the “inositols” on PCOS. I was initially very skeptical, but after some reading, looking into reviews, and ordering some to try myself… I can confidently say that I am a believer in this product and it’s results!

So what is inositol and how does it work?

In women with PCOS or Insulin Resistance, there is a disruption in the system of how the body effectively utilizes the insulin it produces. When this insulin is not being used, it is stored in the body as fat and free radicals causing a myriad of problems for women with PCOS. Inositol (there are 9 different types but not all are effective for managing PCOS), particularly Myo and D-Chiro Inositol act as a glucose to transport the insulin to where it needs to go in order to be effectively used in the body.

For women with PCOS, when you have a disruption in the usage of insulin, your body has to continue to make more insulin to try to regulate your blood sugar. When this happens, it causes inflammation in the ovaries which prevents ovulation and ultimately results in your body producing and releasing male hormones like testosterone. It also causes under-production of estrogen and over production of Leutinizing Hormone, which can also become a major problem when using OPT or OPK to predict ovulation.

“Insulin has multiple effects on metabolism, which can be classified as metabolic and mitogenic. Metabolic effects can be further divided into those related to glucose transport and to glycogen synthesis. These dual metabolic effects sometimes occur in discordance with each other.

This suggests the existence of more than one downstream insulin signaling pathway. While the dominant action occurs though the insulin [secondary] messengers, inositol glycans also mediate many metabolic actions of insulin. The inositol glycans are insulinomimetic, and have an activating/sensitizing effect.” (Kalra, 2016.)

What could this mean for women with PCOS?

Studies have shown that MI and DCI can not only reduce insulin resistance, but that they can also improve the ovarian function, while also reducing androgen levels in women affected by PCOS.

What brand would I recommend?

When I began trying to figure out which brand of Insositol to purchase, I came across excellent reviews on the Wholesome Story Brand of the combined MI and DCI.

Disclaimer: Some of the links included in this post are affiliate links, which means at no cost to you, I will earn a small commission from your purchase.


In the following notes from the study linked below, you can see that the combination of MI and DCI proved to be very effective for women with PCOS, obesity, and insulin resistance.

“In a randomized controlled trial conducted in fifty obese PCOS women, a combination of 550 mg MI and 13.6 mg DCI, in capsule formulation, was found better than 2 g powdered MI, at improving metabolic, endocrine, and ovulation parameters, when administered twice daily over 6 months.Another study showed a significant improvement in insulin sensitivity as well as lipid profile in such patients.

In a large study of 100 women, MI and DCI combination (1.1 g and 27.6 mg, respectively) was found to improve oocyte quality, embryo quality, and pregnancy rates, during in vitro fertilization.” (Kalra, 2016).

If you think this could be something beneficial for you, let me know in the comments below. And as always, I am not a doctor, so it’s a good idea to check with your doctor, Reproductive Endocrinologist, or OBGYN before starting anything new. 🙂


Kalra, B., Kalra, S., & Sharma, J. B. (2016). The inositols and polycystic ovary syndrome. Indian journal of endocrinology and metabolism20(5), 720–724.

Marshall, J. C., & Dunaif, A. (2012). Should all women with PCOS be treated for insulin resistance?. Fertility and sterility97(1), 18–22.

2 thoughts on “Insulin Resistance and Inositol

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